Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/191909753?client_source=feed&format=rss
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Friday, January 27, 2012
Thursday, January 26, 2012
A leukemia drug kills cancerous T-cells while sparing normal immunity
Wednesday, January 25, 2012
Leukemic cutaneous T-cell lymphoma (L-CTCL) is a leukemia arising from T-cells, a type of white blood cell. This cancer can involve the skin and other organs, and patients often die within three years.
Rachael A. Clark, MD, PhD, BWH assistant professor of dermatology and associate dermatologist and Thomas Kupper, MD, BWH Department of Dermatology chairman and their colleagues now report a new study that low-dose Campath (alemtuzumab) not only treats patients with L-CTCL but does so without increasing their risk of infections.
The study was electronically published on January 18, 2012 in Science Translational Medicine.
Campath was previously believed to kill all lymphocytes (T-cells and B-cells) in the body and render patients susceptible to infections. However, Clark and Kupper found that Campath only kills T-cells that enter the bloodstream, but it spares a newly discovered population of T-cells that live long-term in the tissues.
"We noticed that our patients were not getting infections, and we looked in the skin. We saw healthy T-cells remaining there despite the fact that there were no T-cells in the blood," said Clark. "We used to believe that most T-cells responsible for protecting against infection were in the bloodstream. But we now realize that highly protective T-cells also inhabit tissues such as the skin, lungs and gastrointestinal tract. It is these tissue resident T-cells that are critical in protecting us from infection on a day-to-day basis."
By showing that Campath kills circulating T-cells, including the cancerous T-cells, but spares tissue resident T-cells, Clark and Kupper have shown that Campath effectively treats L-CTCL while sparing normal immunity. Their findings are also the first demonstration in human beings that tissue resident T-cells provide frontline immune protection of the skin.
"We're very grateful to our patients for entrusting us with their care and for teaching us important lessons about the immune system." said Clark.
In a companion piece, Mark Davis, PhD, Stanford University School of Medicine, called the work a "translational tour de force."
###
Brigham and Women's Hospital: http://www.brighamandwomens.org
Thanks to Brigham and Women's Hospital for this article.
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Paterno funeral draws legions four days after death (Reuters)
STATE COLLEGE, Pa (Reuters) ? Thousands lined the frigid streets while family and friends of former Penn State football coach Joe Paterno gathered inside a private funeral hall on Wednesday to mourn a man whose towering image was shaken by his inaction in a child sex abuse scandal.
Fired in November after 46 years as head coach, a major college record 409 victories and two national championships, Paterno was celebrated by fans who chose to remember a triumphant coach with a motto of "Success with Honor" rather than a man dismissed unceremoniously by the university board of trustees.
The burial was set for later on Wednesday, with a final public memorial due on Thursday. Paterno died of lung cancer on Sunday. He was 85.
Tens of thousands of people lined the street outside the campus Pasquerilla Spiritual Center in response to a campaign on Facebook to "Guide Joe Paterno Home," forming a gantlet covering much of the mile and half to Beaver Stadium, where Paterno coached for over four decades.
"It shows how much of an icon he was and how many hearts he touched directly and indirectly," said Christina Flanaghan, 21, a junior at Penn State from Philadelphia.
"It means that this man means a lot to people," said Devon DeGilio, 19, a freshman from Morristown, New Jersey.
The massive outpouring attempted to wash away the tarnished image of Paterno, who exposed himself to criticism by failing to intervene more forcefully when he was told in 2002 of an accusation that former defensive coordinator Jerry Sandusky molested a young boy in the Penn State football showers.
Sandusky, 67, who maintains his innocence, faces 52 criminal counts accusing him of molesting 10 boys over 15 years, using his position as head of The Second Mile, a charity dedicated to helping troubled children, to find his victims. The court has placed him under house arrest.
Among those attending the funeral was former quarterback Mike McQueary, who as a graduate assistant in 2002 told Paterno he walked in on Sandusky molesting a boy in the showers.
Paterno told university officials but not police.
Also attending was former Penn State and Pittsburgh Steelers running back Franco Harris, perhaps the biggest star to play for Paterno, who was better known for turning out great linebackers with Sandusky's help.
Some 27,000 mourners passed by Paterno's closed casket for a viewing on Tuesday and a further 10,000 on Wednesday, said Bob Smith, director of the Pasquerilla Spiritual Center.
Wednesday's viewing was to have begun at 8 a.m., but the doors opened closer to 7:30 a.m., Smith said, because of a line that at one stage stretched for more than a block from the center, three and four abreast.
"When we got here at 5:30 a.m.," he said, "the line was already forming."
Among the final mourners was actor Billy Baldwin, who did not attend Penn State but who attended many wrestling matches at there in the 1980s. During that time, he said, he got to know Paterno, and had had dinner at the Paterno home.
"I can't use words to describe the enormous, immense level of respect I have for the guy," Baldwin said.
(Reporting by Dave Warner; Writing by Daniel Trotta; Editing by Cynthia Johnston)
Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/nm/20120125/us_nm/us_usa_paterno
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Friday, January 20, 2012
Burnaby set to renew licence with community gardens group
The Burnaby and Region Allotment Gardens Association (BARAGA) is so successful, it has a waitlist of 95 Burnaby residents.
In no longer keeps a waitlist for non-Burnaby residents since it's unlikely any of those people would get a garden plot in the near future, according to a city staff report.
Burnaby council was expected to approve a renewal on Monday of the city's five-year licence agreement with the group for the 14 acres of city-owned land in the Big Bend area of the city. BARAGA, a non-profit volunteer group, manages 374 garden plots on the property. On average, only 10 to 15 plots each year are freed up to people on the waitlist.
BARAGA recently set aside a plot for the use of students from Maywood Community School, with all the produce grown to go to families from the school. That's in addition to about 2,000 pounds of fruits and vegetables grown at the community garden which are donated to the food bank each year.
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Millions of dollars in capital funding were to be considered by Burnaby council Monday, including $5.6 million for a pavement overlay program to restore deteriorated roadways. Of that, $2.5 million will be reimbursed by TransLink if the program goes ahead.
If approved, $200,000 could be spent on replacing LED traffic signal lights, $600,000 on replacement of about 150 of the most deteriorated streetlight poles, and $65,000 on traffic control upgrades such as crosswalk and turning lane upgrades, signage and other minor hardware replacement.
Council was also to consider approving the replacement of 14 km of watermains in the city, due to age and the need for increased capacity for firefighting and increase population, at a cost of $8 million.
Another $8 million in combined sewer separation and replacement of aging sewer lines is also being proposed.
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Buckingham elementary school is holding 50th anniversary celebrations on Sept. 29. If council approves a recommendation of its executive committee, the city's Festivals Burnaby program could be contributing a $3,000-grant to the event.
The one-day event will be open to the public. The school is unique in that many of its current students are grandchildren of the original students, or are children of parents who once attended, according to a committee report.
wchow@burnabynewsleader.com
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Source: http://www.bclocalnews.com/business/137510088.html
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Thursday, January 19, 2012
Q&A: Cincinnati coach Butch Jones, Part II
If you missed it, here is Part I of my interview with Cincinnati coach Butch Jones. Today, Jones goes over some of the key questions headed into spring practice, which begins March 1.
Did you allow yourself any time to enjoy the season after the bowl win or did you rush into preparations for 2012?
BJ: We started working on 2012 during bowl prep. We wanted to finish, but were also were getting ready for the future. We stayed after in Memphis so we could enjoy the win, took a day and then we were full-fledged onto 2012. That's the thing in our profession -- you can never sit back. I thought we did some great things with bowl prep. We had our seniors meet with the junior class and talk about leadership and the things they learned.
So on to the future, what happens at the quarterback spot? Munchie Legaux and Jordan Luallen got playing time this year, so they have to be the leaders, right?
BJ: They're going to have to earn that position every day. The exciting thing is with all the youth that we have and the competition that we have, there's already a renewed spirit, there?s a renewed commitment, there's excitement and energy in our football program. That's not just with the quarterback spot. I can feel that excitement already. I think the experience that Munchie gained and Jordan gained will prove to be extremely beneficial as we move forward. But it?s also exciting because of Patrick Coyne, Brendon Kay. Throw in two youngsters who graduated high school early -- to have them here already is going to pay huge dividends as well.
What do you think when people think 2012 will be a rebuilding year? I?ve written it myself.
BJ: All we can control is ourselves -- continuing to build our football program, and not paying attention. You look at last year -- I have it sitting on my desk -- you look at preseason rankings in the Big East conference and you look at the positions. Every single one of our defensive positions was ranked 7 or 8 in our conference. The thing we have to do is focus on being a better football team. It's what you sign your name to -- it's that excellence we talk about. I don't get caught up in the outside world because I know what we have, our players know what we have. We talk about not building a team but a program, and I think we have proven across the country we are a football program. So we just have to control what we can control, our daily work ethic, how we go to class, every individual taking accountability. There's a lot of excitement here in the community and in our football program. I think change is good, change keeps people on their toes. There's a lot of competition, our junior class that are now seniors they understand the responsibility that it is in our football program. There's a great spirit right now.
Where do you think is your biggest area of strength going into 2012?
BJ: Well, we won a lot of games on special teams this year. You look at starting season with an unproven kicker, Tony (Miliano) has a lot of room for improvement, but he also made big kicks for us, Pat O?Donnell returns as well. In our secondary, those individuals have gained a ton of experience, Deven Drane continued to get better as the season progressed, along with Cam Cheatham. Now we have Trenier Orr, whom we?re high on, so we?re going to have a high level of competition. We get Dominique Battle back. You look at our defensive end position with Walter Stewart and Brandon Mills, Dan Giordano so that and then I expect our receiving corps to be much better with Anthony McClung, Kenbrell Thompkins, Alex Chisum and the experience they gained. Also, I thought our tight ends really made some big plays for us. We?re going to miss Adrien Robinson, but that's a position that could be pretty strong as well.
How about at running back? You seem to have a lot of depth there when it comes to trying to replace Isaiah Pead.
BJ: I don't know if you just replace a great back like Isaiah. He meant so much to us but that's probably one of the most competitive spots that we'll have in our football program. When you look at Ralph David Abernathy and what he brings to the table, that big kickoff return (against Vanderbilt), Jameel Poteat, Akise Teague, George Winn. And if we?re able to maintain a couple in the recruitment process, I think that's going to be a very, very competitive position as we move forward and we'll see how it goes. The mark of great coaches is they're able to adapt each and every year for their strengths and weaknesses so we have to do a great job of playing to our strength. Each team have a different personality. We just have to do a great job of putting our schemes in and allowing players to be successful in what they can do.
Source: http://espn.go.com/blog/bigeast/post/_/id/29109/qa-cincinnati-coach-butch-jones-part-ii
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'Artist,' 'Tinker Tailor' up for UK film awards (AP)
LONDON ? It's spry versus spy as frothy silent movie "The Artist" and moody thriller "Tinker Tailor Soldier Spy" lead the race for the British Academy Film Awards, Britain's equivalent of the Oscars.
"The Artist" received 12 nominations and "Tinker Tailor" 11, with each film up for best picture and director, and best actor nominations for leading men Jean Dujardin and Gary Oldman.
The other best-film nominees, announced at a ceremony Tuesday by actors Daniel Radcliffe and Holliday Grainger, were "The Descendants," "Drive" and "The Help."
In a diverse field not dominated by any single film, there are also multiple nominations for "Hugo," "My Week With Marilyn," "The Iron Lady" and "The Help."
The nominations are another feather in the cap of "The Artist," a black and white French film about a silent screen star's fall with the rise of talkies that has become an unlikely hit. On Sunday it won three Golden Globes, including best musical or comedy film.
Director Michael Hazanavicius said Tuesday he and his crew had been "a bit mad to make a black-and-white silent film in 2011."
"We certainly hoped to find an audience, but the support we have received from so many people in so many different countries was unexpected, overwhelming and quite wonderful," he said.
The shortlist gives a boost to "Tinker Tailor," an atmospheric adaptation of John le Carre's espionage classic that has received rave reviews but has so far been snubbed during the U.S. awards season.
"Tinker Tailor" producer Tim Bevan said the film was a "particularly British cultural phenomenon. It's great that it's being recognized at the BAFTAs but that it hasn't at the Golden Globes is not surprising."
"'The Artist' seems to be the film with the momentum, and rightly so," he said. "It's been an OK year but not a brilliant year for movies, and 'The Artist' defines what cinema should be. It's brave, different, it's got a great shot."
The best actor contest pits Oldman and Dujardin against Brad Pitt for "Moneyball," George Clooney for "The Descendants" and Michael Fassbender for "Shame."
The best actress category includes two performers playing real-life icons ? Michelle Williams as Marilyn Monroe in "My Week With Marilyn" and Meryl Streep as former Prime Minister Margaret Thatcher in "The Iron Lady."
Streep, who has been widely praised for her performance, said the nomination was "thrilling news ... Not just for me, but for the film of which I am very proud, and for the hundreds of people who worked on it! Thanks, from a (New) Jersey girl."
The other nominees are Berenice Bejo for "The Artist," Tilda Swinton for "We Need to Talk About Kevin" and Viola Davis for "The Help."
The prizes will be awarded at a ceremony at London's Royal Opera House on Feb. 12. They are considered an important indicator of prospects at the Academy Awards in Los Angeles two weeks later.
In recent years, the awards, known as BAFTAs, have helped small British films gain momentum for Hollywood success.
In 2010, Danny Boyle's "Slumdog Millionaire" won seven BAFTAs, including best film; it went on to take eight Oscars. Last year "The King's Speech" won seven BAFTAs and four Oscars, including best picture.
"My Week With Marilyn," the story of the movie legend's time shooting an ill-starred comedy in England, received six BAFTA nominations, including a supporting-actor nod for Kenneth Branagh, who plays Laurence Olivier.
He is up against Christopher Plummer for "Beginners," Jim Broadbent for "The Iron Lady," Jonah Hill for "Moneyball" and Philip Seymour Hoffman for "The Ides of March."
The supporting actress category features Carey Mulligan for "Drive," Jessica Chastain for "The Help," Judi Dench for "My Week With Marilyn," Melissa McCarthy for "Bridesmaids" and Octavia Spencer for "The Help."
The multinational best-director contest pits Hazanavicius against Denmark's Nicholas Winding Refn, for the turbocharged "Drive," Sweden's Tomas Alfredson for "Tinker Tailor," Britain's Lynne Ramsay for "We Need to Talk About Kevin" and Martin Scorsese of the United States for "Hugo."
The best British film category contains "My Week With Marilyn," racing documentary "Senna," sex-addiction drama "Shame," family tragedy "We Need to Talk About Kevin" and "Tinker Tailor Soldier Spy."
Steven Spielberg's equine adventure "War Horse" was overlooked in the major categories but gained five nominations, including cinematography, visual effects and music.
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On the Net: http://www.bafta.org
Jill Lawless can be reached at: http://twitter.com/JillLawless
(This version CORRECTS Corrects first name of supporting actress nominee Octavia Spencer.)
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Wednesday, January 18, 2012
More accustomed to rain, Seattle braces for snow
In this photo taken Sunday, Jan. 15, 2012, Maliah Bowden, 13, tries to catch a snow flake in her mouth, in Manette, Wash. (AP Photo/Kitsap Sun, Larry Steagall)
In this photo taken Sunday, Jan. 15, 2012, Maliah Bowden, 13, tries to catch a snow flake in her mouth, in Manette, Wash. (AP Photo/Kitsap Sun, Larry Steagall)
A light snow falls as a visitor to Heritage Park in downtown Olympia, Wash. enjoys a quiet walk on the Martin Luther King Jr. holiday Monday, Jan. 16, 2012. (AP Photo/The Olympian, Steve Bloom)
Victims of a snowy crash stand at right as an Oregon Department of Transportation employee, in vest, checks with another driver after winter weather hit the area in Beaverton, Ore., Tuesday, Jan. 17, 2012. he National Weather Service has issued a winter storm warning for much of Oregon through Wednesday for heavy snow.(AP Photo/Don Ryan)
An Oregon Department of Transportation employee checks on a crash victim in Beaverton, Ore., Tuesday, Jan. 17, 2012. The National Weather Service has issued a winter storm warning for much of Oregon through Wednesday for heavy snow.(AP Photo/Don Ryan)
People walk across the tracks during a snow storm id-afternoon Monday, Jan. 16, 2012 at the TriMet Gateway Transit Center in Northeast Portland, Ore. (AP Photo/The Oregonian, Randy L. Rasmussen) MAGS OUT; NO SALES; TV OUT
SEATTLE (AP) ? Seattle, a city more accustomed to rain than snow, prepared Tuesday for a potentially major snowstorm to hit as the city's mayor urged residents to stay off roads.
Many school districts in the western part of the state, including Seattle, canceled classes for Wednesday, when the area was expected to get several more inches of snow.
Snow has been falling steadily in parts of western Washington and Oregon since the weekend, but National Weather Service meteorologists said the biggest amounts could come on Wednesday. The new round of snow was expected to start falling just before the morning rush hour in the Seattle area, meteorologist Doug McDonnal said.
"Wednesday is going to be a good day to stay at home," said Brad Colman, another Weather Service meteorologist in Seattle. "The road is going to be treacherous."
The Seattle metropolitan area could get 3 to 5 inches of snow, with 3 to 6 inches in the Olympia area and 1 to 2 inches north of Seattle. The Cascade Mountains could see 1 to 3 feet of new snow through late Wednesday.
If the past is any hint, even several inches of snow has the potential to paralyze the city of Seattle. The city owns relatively few snowplows, and Seattle drivers are mostly inexperienced with driving in snow or ice.
Crews were salting and sanding streets, some local agencies prepared to open emergency shelters and commuters made plans to stay at home. Officials warned of high avalanche danger in the Cascades.
Bec Thomas, who lives Camano Island north of Seattle, was hunkering down. She stocked up on bottled water and food. While her children built snowmen, made snow angels and sledded in nearly a foot of fresh snow, she made food that could be reheated on her woodstove.
The last snowstorm knocked out her power for a week.
"We take it very seriously," said Thomas, a fine arts photographer. "We'll probably be snowed in until Thursday."
John Lee, a graphic designer who lives in Mill Creek north of Seattle, decided to work from home Tuesday when he looked out his window and saw several inches of snow on the ground and more falling.
"Snow is beautiful to look at but it's kind of a hindrance for us to work and commute," said Lee, 23, who works in Seattle. "This is the first snow we've seen all season, so it's a bit exciting in that way. I hope it doesn't escalate to something bigger."
The weather service issued a winter storm warning from Tuesday night to Wednesday night for much of Western Washington. A storm warning was also issued for much of eastern Washington from early Wednesday to Thursday night.
Snow from the new storm was expected to start falling first on the Washington coast, where conditions will also be windy.
Forecasters predicted that about 6 inches of snow could fall on Spokane by Wednesday with several more inches falling Thursday. The Pullman area could see as much as 12 inches of new snow by Wednesday night.
Washington state troopers advised motorists to plan ahead and be prepared.
"The No. 1 thing is to drive for the road conditions," Trooper Keith Leary said. "People need to slow down, take their time. If they're not prepared, don't get out on the roadways."
In Oregon, log trucks spun out on ice, school districts closed bus routes and colleges cancelled early classes. The amount of actual snowfall varied across the state, but traffic accidents and clogged roadways were the norm across a northern strip of the state that extended from the coast to the Cascades and included the northern lowlands in the Willamette Valley.
Snow has steadily been falling in Olympia since Sunday, and large snowflakes continued to fall Tuesday with several inches on the ground at the Capitol.
In Portland, the city was still stinging from the fallout of a 2008 winter snowstorm that caused major traffic backups and public transportation delays.
This year, the city's Bureau of Transportation spread a de-icing solution over major roadways. The solution, calcium magnesium acetate, is considered less toxic and non-corrosive.
Portland does not use rock salt to prevent ice.
"We're not expecting huge accumulations of snow," said Bureau of Transportation spokeswoman Cheryl Kuck. "But we're ready for anything."
Snow on Tuesday canceled or delayed classes in many school districts in the region. Seattle Public Schools, the state's largest school district, closed schools two hours early on Tuesday.
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AP Writer Rachel La Corte in Olympia and Donna Blankinship in Seattle contributed to this report.
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Make Pill Bottles Easier to Open with Sugru [Sugru]
If you or a family member has arthritis opening standard child-safety pill bottles can be a real pain. Use a bit of Sugru to give the lid a textured grip that makes it easier to open.
This idea comes from Instructables user Surfer24. All you need for this hack is to open a packet of Sugru and mold it into a long "snake" shape. Wrap the Sugru around the the bottle lid tightly and let it cure for 24 hours before use.
If the same prescription is used every month remember to keep the lid to transfer to the new pill bottle. If you don't already have Sugru on hand you can order it from the official website for as little as 6 packets for $12.
Sugru Pill Bottle Hack | Instructables
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Wednesday, January 11, 2012
CDC: Young adults down 9 drinks when they binge (AP)
ATLANTA ? New government statistics show college-age binge drinkers average an astounding nine drinks each time they get drunk.
Binge drinking is when someone consumes four or five alcoholic beverages on one occasion. Health officials lament it contributes to problems like drunk-driving accidents, violence and fetal alcohol syndrome.
About 17 percent of the adults surveyed said they'd had an episode of binge drinking in the previous month. It was more common for those ages 18 to 34.
The report is based on telephone surveys last year of more than 450,000 U.S. adults. The Centers for Disease Control and Prevention released it on Tuesday.
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Online:
CDC report: http://www.cdc.gov/vitalsigns
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